The framework and support structure for our body tissues and organs
Connective tissue connects, supports, binds, and separates organs and tissues, forming a framework to support body tissues and organs, for structural and metabolic purposes. In connective tissue, cells are few and dispersed — they are not in close contact, as in epithelial tissue. Most connective tissues are vascularized (except cartilage). The extracellular spaces (space outside of cells) in connective tissue are referred to as the extracellular matrix. Resin Bonded Mineral Wool
Connective tissue, therefore, is made up of cells and extracellular matrix. The extracellular matrix is composed of glycosaminoglycans and proteoglycans. It is variations in the composition of the extracellular matrix that determine properties of the connective tissue.
Connective tissue is made up of:
Connective tissue proper is classified as either loose irregular connective tissue or dense irregular connective tissue.
Under normal circumstances, the fibers, proteoglycan, and GAGs are regulated and controlled by a balance between synthesis and degradation. The balance is maintained by cytokines, growth factors, and degradative MMPs (matrix metalloproteinases). If there is an imbalance, connective tissue diseases can develop. For example, there is a net degradation in conditions such as osteoarthritis, rheumatoid arthritis, and osteoporosis. A net increase in synthesis can lead to scleroderma or interstitial pulmonary fibrosis.
There are more than 200 diseases and conditions that affect connective tissue. Some connective tissue diseases are consequences of infection, autoimmune diseases, injury, or genetic abnormalities. The cause of some connective tissue diseases remains unknown.
By Carol Eustice Carol Eustice is a writer covering arthritis and chronic illness, who herself has been diagnosed with both rheumatoid arthritis and osteoarthritis.
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